Missouri is one of the fastest growing cannabis markets in the United States. As of 2025, Missouri is sitting at 4.6% growth year over year (per Headset). The adult-use market is relatively newer; their recreational market opened in February 2023 but sales have been steady since launch. There are 67 active cultivation licenses in Missouri currently that are all fighting for shelf space and market share, and that’s not including the microbusinesses or the licenses yet to be issued. Missouri operators need the right tools to secure a top spot in this fast-moving industry. 

Here’s Everything You Need to Scale Your Missouri Cannabis Business in 2025

Automated Metrc Integration 

Missouri’s state compliance system is Metrc, the leading state cannabis compliance system in the United States. There are many operators who rely on manual entry for tracking plants and products, however manual entry leaves a lot of room for risk. The compliance fees and fines significantly outweigh the cost of trustworthy compliance software. Competitive operators in Missouri are actively looking for cannabis software with an automated metrc integration to avoid manual entry errors. The leading cannabis ERP systems, like 365 Cannabis, are designed with compliance guardrails to ensure users stay within regulations at every step, something we pride ourselves on.  

Real-Time Inventory Control 

As a company grows, so do their assets and that includes every seed, every gram, every gummy. Having instant access to all products across cultivation, manufacturing, and retail is a non-negotiable for the leading Missouri cannabis operators. Real-time inventory control gives operators instant visibility into every SKU, eliminating blind spots and costly write-offs. The right cannabis software will track take account of everything within the supply chain and production schedule and be able to deliver Available-to-Purchase (ATP) data for sales (and here’s why that’s important).  

Integrated Cannabis-Focused Financial Tools 

Missouri’s cannabis community is booming and that means more money to manage for operators. Many businesses, cannabis or not, use QuickBooks. That’s a fair tool for some businesses, but it’s not designed or optimized at all for cannabis operators. Cannabis has unique challenges as a federally illegal, state legal, Schedule I substance subject to 280E. Outside of the QuickBooks limitations, due to cannabis being federally illegal, they do reserve the right to not support any cannabis enterprises, even fully legal and licensed ones. We’ve seen reported issues with QuickBooks as early as 2015 of entire financial recording software locked overnight. While QuickBooks does often turn a blind eye, they overall do not serve the needs of the cannabis community. ERP platforms have financial systems built into place that serve two functions- eliminating the need for third party financials like QuickBooks and integrating all efforts to ensure financial data is accurate. The 365 Cannabis financial module for example pulls financial data in from all sales, all purchases, all invoices, everywhere that touches the business to ensure every penny is accounted for. Native financial functions reduce the opportunity for human error and ensure every spend and every sale is accounted for.  

Data and Analytics for Decision Making  

Missouri’s cannabis market is still relatively young, which means consumer behavior is evolving quickly. Operators who rely only on historic sales data risk missing major shifts in category demand. Advanced analytics provide real-time visibility into product performance, costs, and margins, helping operators pivot quickly and stay ahead of competitors. Dashboards powered by tools like Microsoft’s Power BI allow businesses to identify growth categories, spot inefficiencies, and make data-driven decisions with confidence. In a fast-moving market, analytics are the difference between reacting to trends and leading them. 

Missouri cannabis operators are competing in one of the most dynamic markets in the country. Success in Missouri’s cannabis market demands excellence in compliance, product visibility, accuracy, finance, and control across the entire business. ERP built for cannabis, like 365 Cannabis, combines compliance, inventory, financials, and analytics into one platform designed for growth. 

If you’re ready to scale your Missouri cannabis operation, schedule a demo with 365 Cannabis and see how ERP can help you lead the market.